Under the combined influence of various etiological factors at work on different sections of the skeletal system, the osteal tissues undergo degenerative changes and normal blood flow to the osteal tissues is disrupted. This in turn raises the Intraosseous pressure and causes the irritation of Intraosseous receptors (IOR). Increased afferentation from the IOR helps in the transmission of other Afferent impulses, strengthening of the motor reaction and reduction of the corticofugal effect on the segements involved. The factors mentioned above are responsible for the typical clinical symptoms seen in Neuroorthopedic diseases: pain, myotonic, angiospastic and hypotrophic syndromes.

The combination of symptoms depends on the presence of "target-tissues" in the segmental region concerned to irritated IOR. For example, in vetebral ostiochondritis, hyperafferentation from the IOR may clinically manifest in various forms: in the lumbar region - on the many kinds of tissues present there, in the cervical region - on the vertebral artery additionally, in the thoracic region - as vertebro-visceral syndromes affecting internal organs. Hyperafferentation from the IOR in the various bones of the skull clinically present most frequently as pain and vascular-tonic syndromes or rarely as muscular-tonic syndrome in the region of the face and head.

The basic principle governing the effectiveness of various therapeutic methods like the trepanation of the bone’s cortical layer, tunnelisation, osteoreflexotherapy, intraosseous blockades, osteokreodestruction etc, all of which are based on the direct involvement of the spongia, is the normalization of intraosseous pressure which in turn leads to the regression of Neuroorthopedic syndroms through the mechanisms mentioned above.